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Cancer Chemotherapy Regimen for Head and Neck Cancer


 BMVL                                                head_neck(67)
 _________________________________________________________________
  bleomycin....... 10 U (first course); 20 U (2nd to 6th course) 
                   SC on days 1 and 4.
  methotrexate.... 20 mg orally on days 1 and 4.
  vinblastine..... 8 mg/sqm IV day 1.
  lomustine....... 175 mg/sqm orally day 1.
  FREQUENCY....... Repeat cycle every 4 to 6 weeks, depending on 
                   WBC counts.


  reference...
    Huang AT.  Lucas VS.  Baughn SG.  Cole TB. A trial of 
    outpatient chemotherapy for recurrent head and neck tumors. 
    Cancer.  45(8):2038-41, 1980 Apr 15. 
  abstract...
    A four-drug combination chemotherapy 
    (bleomycin-methotrexate-vinblastine-CCNU) had been used in 38 
    evaluable patients with recurrent squamous cell carcinoma of 
    the head and neck region on an outpatient basis. A large 
    number of these patients had carcinoma of the oral cavity (45% 
    of total). Nineteen patients (50%) responded to this regimen 
    with a greater than or equal to 50% regression of their 
    measured tumors. The median survival of all patients was 34 
    weeks. There was one chemotherapy-related death and the 
    overall toxicity was mild. This convenient regimen can be 
    considered a useful alternative to more aggressive therapy. 
 

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