Cancer Chemotherapy Regimen for Head and Neck Cancer
BMVL head_neck(67) _________________________________________________________________ bleomycin....... 10 U (first course); 20 U (2nd to 6th course) SC on days 1 and 4. methotrexate.... 20 mg orally on days 1 and 4. vinblastine..... 8 mg/sqm IV day 1. lomustine....... 175 mg/sqm orally day 1. FREQUENCY....... Repeat cycle every 4 to 6 weeks, depending on WBC counts. reference... Huang AT. Lucas VS. Baughn SG. Cole TB. A trial of outpatient chemotherapy for recurrent head and neck tumors. Cancer. 45(8):2038-41, 1980 Apr 15. abstract... A four-drug combination chemotherapy (bleomycin-methotrexate-vinblastine-CCNU) had been used in 38 evaluable patients with recurrent squamous cell carcinoma of the head and neck region on an outpatient basis. A large number of these patients had carcinoma of the oral cavity (45% of total). Nineteen patients (50%) responded to this regimen with a greater than or equal to 50% regression of their measured tumors. The median survival of all patients was 34 weeks. There was one chemotherapy-related death and the overall toxicity was mild. This convenient regimen can be considered a useful alternative to more aggressive therapy.
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