bleomycin....... 30 U IV day 2, then weekly times 6 weeks.
adriamycin...... 40 mg/sqm IV day 1, then every 4 weeks.
lomustine....... 65 mg/sqm orally day 1, then every 8 weeks.
vincristine..... 0.75 to 1.0 mg/sqm IV day 2, then weekly times
mechlorethamine. 8 mg/sqm IV day 1, then every 4 weeks.
FREQUENCY....... Specified above.
Livingston RB. Fee WH. Einhorn LH. Burgess MA. Freireich
EJ. Gottlieb JA. Farber MO. BACON (bleomycin, adriamycin,
CCNU, oncovin and nitrogen mustard) in squamous lung cancer.
Experience in fifty patients. Cancer. 37(3):1237-42, 1976
Fifty patients with inoperable squamous carcinoma of the lung.
38 with extensive, and 12 with limited disease, were treated
with BACON. Tumor regression greater than 50% was observed in
17 patients (45%) with extensive, and four patients (33%) with
limited disease. Stabilization of disease for greater than or
equal to 8 weeks was seen in four extensive and eight limited
patients, and had the same prognostic importance with regard
to survival as response: in extensive disease, responding and
stable patients had median survival (MST) of 26 weeks from
start of therapy, while MST for non-responders was 9 weeks.
MST in limited disease (all patients responding or stable) was
32 weeks. Analysis of survival in extensive disease by
performance status showed improvement in each category over
historical control results for supportive care alone. BACON
was better tolerated and probably more effective when CCNU was
given every 8 weeks, rather than every 4 weeks.