cytoxan......... 300 mg/sqm IV on days 1 and 8.
adriamycin...... 20 mg/sqm IV on days 1 and 8.
methotrexate.... 15 mg/sqm IV on days 1 and 8.
procarbazine.... 100 mg/day orally for 10 days.
FREQUENCY....... Repeat cycle every 28 days.
Bitran JD. Desser RK. DeMeester TR. Colman M. Evans R.
Billings A. Griem M. Rubenstein L. Shapiro C. Golomb HM.
Cyclophosphamide, adriamycin, methotrexate, and procarbazine
(CAMP)--effective four-drug combination chemotherapy for
metastatic non-oat cell bronchogenic carcinoma. Cancer
Treatment Reports. 60(9):1225-30, 1976 Sep.
Twenty-three patients with metastatic non-oat cell
bronchogenic carcinoma (MNOBC) were treated with
cyclophosphamide, adriamycin, methotrexate, and procarbazine
(CAMP) after radiation therapy. Objective responses were seen
in 11 of 23 patients (48%) with a projected median survival
time of 12.5 months for responding patients and patients with
stable disease. Lung, liver, and cutaneous sites of
involvement proved to be highly responsive; bone involvement
was less responsive. CAMP is an effective combination in the
treatment of MNOBC and its use in patients with less advanced
disease should be explored.