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Cancer Chemotherapy Regimen for Non-small Cell Lung Cancer


 6-DRUG
_________________________________________________________________
  bleomycin....... 15 U/sqm IV day 1.
  methotrexate.... 60 mg/sqm IV day 1.
  vinblastine..... 4 mg/sqm IV day 1.
  fluorouracil.... 1,000 mg/sqm IV day 1.
  cisplatin....... 40 mg/sqm IV day 1.
  leucovorin...... 10 mg/sqm orally every 6 h times four beginning 
                   24 h after methotrexate.
  FREQUENCY....... Give second cycle when red cell deformity has 
                   increased > 25% above day 1 value (4 to 6 
                   days). Subsequent cycles are given after 
                   hematologic recovery.

  reference...
    Citron ML.  Fossieck BE Jr.  Krasnow SH.  Johnston-Early A.  
    Cohen MH. Superior vena cava syndrome due to non--small-cell 
    lung cancer. Resolution with chemotherapy alone. JAMA.  
    250(1):71-2, 1983 Jul 1. 
  abstract...
    Three patients with superior vena cava syndrome due to 
    non--small-cell lung cancer were treated with chemotherapy 
    alone. Symptomatic relief began within three days of treatment 
    and substantial resolution of the syndrome occurred in all 
    three patients. One patient had complete remission of tumor 
    and the other two had more than a 50% tumor reduction within 
    the first month of therapy. These are the first case reports 
    indicating that combination chemotherapy may be effective as 
    initial management of the superior vena cava syndrome due to 
    non--small-cell lung cancer. 

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