Cancer Chemotherapy Regimen for Non-small Cell Lung Cancer
6-DRUG _________________________________________________________________ bleomycin....... 15 U/sqm IV day 1. methotrexate.... 60 mg/sqm IV day 1. vinblastine..... 4 mg/sqm IV day 1. fluorouracil.... 1,000 mg/sqm IV day 1. cisplatin....... 40 mg/sqm IV day 1. leucovorin...... 10 mg/sqm orally every 6 h times four beginning 24 h after methotrexate. FREQUENCY....... Give second cycle when red cell deformity has increased > 25% above day 1 value (4 to 6 days). Subsequent cycles are given after hematologic recovery. reference... Citron ML. Fossieck BE Jr. Krasnow SH. Johnston-Early A. Cohen MH. Superior vena cava syndrome due to non--small-cell lung cancer. Resolution with chemotherapy alone. JAMA. 250(1):71-2, 1983 Jul 1. abstract... Three patients with superior vena cava syndrome due to non--small-cell lung cancer were treated with chemotherapy alone. Symptomatic relief began within three days of treatment and substantial resolution of the syndrome occurred in all three patients. One patient had complete remission of tumor and the other two had more than a 50% tumor reduction within the first month of therapy. These are the first case reports indicating that combination chemotherapy may be effective as initial management of the superior vena cava syndrome due to non--small-cell lung cancer.
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