CAV/CM
_________________________________________________________________
  cytoxan......... 750 mg/sqm IV day 1.
  adriamycin...... 50 mg/sqm IV day 1.
  vincristine..... 1 mg IV on day 1, then weekly for 12 weeks.
  FREQUENCY....... Repeat every 3 weeks.

  cytoxan......... 1,000 mg.sqm IV day 1.
  methotrexate.... 30 mg/sqm IV on day 22.
  FREQUENCY....... Repeat every 4 weeks.


  reference...
    Livingston RB.  Moore TN.  Heilbrun L.  Bottomley R.  Lehane 
    D.  Rivkin SE.  Thigpen T. Small-cell carcinoma of the lung: 
    combined chemotherapy and radiation: a Southwest Oncology 
    Group study. Annals of Internal Medicine.  88(2):194-9, 1978 
    Feb. 
  abstract...
    Chemotherapy (doxorubicin, cyclophosphamide, and vincristine) 
    was given in a sequential fashion with radiation of the 
    primary tumor and brain to 358 patients with small-cell lung 
    carcinoma (extensive disease in 250, limited in 108). Complete 
    regression of tumor was obtained in 14% of patients with 
    extensive disease and 41% of patients with limited disease, 
    and complete or partial response in 57% and 75%, respectively. 
    Median survival was 26 weeks for patients with extensive 
    disease and 52 weeks for those with limited disease. Response 
    duration was longer for patients in complete remission; one 
    third had disease-free survival greater than 1 year. Toxicity 
    from the combined treatment modalities was no greater than 
    expected from the components given separately: fatal in 3.9%, 
    and life-threatening but reversible in 8.4% of patients. 
    Whole-brain radiation was effective in preventing isolated 
    relapse at that site. This therapy appears both feasible and 
    effective, with acceptable risks and some benefit to most 
    patients.