C-MOPP                                               lymphoma(88)
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  cytoxan......... 650 mg/sqm IV on days 1 and 8.
  mechlorethamine. 6 mg/sqm IV on days 1 and 8.
  vincristine..... 1.4 mg/sqm IV on days 1 and 8.
  procarbazine.... 100 mg/sqm/day orally from day 1 to day 14.
  prednisone...... 40 mg/sqm/day orally from day 1 to day 14.
  FREQUENCY....... Repeat cycle every 28 days.


  reference...
    DeVita VT Jr.  Canellos GP.  Chabner B.  Schein P.  Hubbard 
    SP.  Young RC. Advanced diffuse histiocytic lymphoma, a 
    potentially curable disease. Lancet.  1(7901):248-50, 1975 Feb 
    1. 
  abstract...
    Twenty-seven patients with advanced diffuse histiocytic 
    lymphoma (reticulum-cell sarcoma) were treated with 
    combination chemotherapy utilising nitrogen mustard (or 
    cyclophosphamide), procarbazine, vincristine, and prednisone. 
    Elven (41%) achieved a complete remission and only one of 
    these has had a recurrence of tumour. The remaining ten 
    complete responders were free of all evidence of tumour when 
    last seen 26-105 months from the end of treatment. In 
    contrast, all non-responders or partial responders have died. 
    An interpretation of published survival data suggests that 
    this virulent disease evolves quickly and is usally rapidly 
    fatal if treatment is unsuccessful. Survival free of disease 
    beyond 2 years from the end of treatment may be considered 
    tantamount to cure. This definition of cure, previously 
    applied only to patients treated with radiotherapy, seems 
    applicable to patients who achieve complete remissions with 
    modern drug treatment.