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Cancer Chemotherapy Regimen for Lymphoma Cancer


 ABP                                                  lymphoma(82)
 _________________________________________________________________
  adriamycin...... 75 mg/sqm IV day 1.
  bleomycin....... 15 U/sqm IV on days 1 and 8.
  prednisone...... 100 mg/sqm/day orally on days 1 to 5.
  FREQUENCY....... Repeat cycle every 21 days.

  reference...
    Bonadonna G.  Monfardini S.  Villa E. Non-cross-resistant 
    combinations in stage IV non-Hodgkin's lymphomas. Cancer 
    Treatment Reports.  61(6):1117-23, 1977 Sep. 
  abstract...
    Two triple-drug combinations (cyclophosphamide, vincristine, 
    and prednisone [CVP] and adriamycin, bleomycin, and prednisone 
    [ABP]) were randomly tested in 57 consecutive patients with 
    pathologic stage IV non-Hodgkin's lymphoma. No statistical 
    difference was observed in the incidence of complete remission 
    (CR) (48% vs 50%), median duration of CR (10.5 vs 20.5 
    months), and survival. CR correlated positively with survival. 
    After crossover for progression or relapse, no cross 
    resistance was detected between the two combinations (CR plus 
    PR = 40% for CVP and 50% for ABP). In a subsequent prospective 
    study CVP and ABP were sequentially alternated in an attempt 
    to improve the incidence and duration of CR. In the first 32 
    evaluable patients CR was produced in 50%. The findings are 
    still preliminary. 
 

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