ABP lymphoma(82)
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adriamycin...... 75 mg/sqm IV day 1.
bleomycin....... 15 U/sqm IV on days 1 and 8.
prednisone...... 100 mg/sqm/day orally on days 1 to 5.
FREQUENCY....... Repeat cycle every 21 days.
reference...
Bonadonna G. Monfardini S. Villa E. Non-cross-resistant
combinations in stage IV non-Hodgkin's lymphomas. Cancer
Treatment Reports. 61(6):1117-23, 1977 Sep.
abstract...
Two triple-drug combinations (cyclophosphamide, vincristine,
and prednisone [CVP] and adriamycin, bleomycin, and prednisone
[ABP]) were randomly tested in 57 consecutive patients with
pathologic stage IV non-Hodgkin's lymphoma. No statistical
difference was observed in the incidence of complete remission
(CR) (48% vs 50%), median duration of CR (10.5 vs 20.5
months), and survival. CR correlated positively with survival.
After crossover for progression or relapse, no cross
resistance was detected between the two combinations (CR plus
PR = 40% for CVP and 50% for ABP). In a subsequent prospective
study CVP and ABP were sequentially alternated in an attempt
to improve the incidence and duration of CR. In the first 32
evaluable patients CR was produced in 50%. The findings are
still preliminary.
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