COMLA                                                lymphoma(89)
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  cytoxan......... 1,500 mg/sqm IV day 1.
  vincristine..... 1.4 mg/sqm IV on days 1, 8, and 15.
  methotrexate.... 120 mg/sqm IV at 3 weeks (day 22) then weekly 
                   times 7 (days 29, 36, 43, 50, 57, 64, and 71).
  leucovorin...... 25 mg/sqm orally every 6 hours times four 
                   starting 24 h after each dose of methotrexate.
  cytarabine...... 300 mg/sqm IV at 3 weeks (day 22), then weekly 
                   times 7 (days 29, 36, 43, 50, 57, 64, and 71).
  FREQUENCY....... Repeat cycle every 13 weeks (91 days).

  reference...
    Berd D.  Cornog J.  DeConti RC.  Levitt M.  Bertino JR. 
    Long-term remission in diffuse histiocytic lymphoma treated 
    with combination sequential chemotherapy. Cancer.  
    35(4):1050-4, 1975 Apr. 
  abstract...
    Seventeen patients with Stage III or IV reticulum cell sarcoma 
    were treated with three cycles of a 5-drug regimen between 
    February, 1969 and December, 1970. Of the 17 patients, 9 
    attained a complete remission and 6 had a parital remission; 2 
    were considered unevaluable. Recently, the original biopsies 
    from these patients were reclassified according to the 
    criteria of rappaport et al. The results were: diffuse 
    histiocytic--8; nodular histiocytic--2; diffuse mixed--2; 
    nodular mixed--3; diffuse lymphocytic poorly 
    differentiated--1; nodular lymphocytic poorly 
    differentiated--1. Of the 8 patients with diffuse histiocytic 
    lymphoma 6 attained complete remission, 1 had a partial 
    remission, and 1 was unevaluable. One of the 6 with complete 
    remission relapsed at 7 months and died 2 months later. 
    However, the other 5 are alive and in continued unmaintained 
    remission for 55 to 65 months.