COP-BLAM                                             lymphoma(90)
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  cytoxan......... 400 mg/sqm IV day 1.
  vincristine..... 1.0 mg/sqm IV day 1.
  prednisone...... 40 mg/sqm/day orally from day 1 to day 10.
  bleomycin....... 15 U IV day 14.
  adriamycin...... 40 mg/sqm IV day 1.
  procarbazine.... 100 mg/sqm/day orally from day 1 to 10.
  FREQUENCY....... Repeat cycle every 21 days.


  reference...
    Laurence J.  Coleman M.  Allen SL.  Silver RT.  Pasmantier M. 
    Combination chemotherapy of advanced diffuse histiocytic 
    lymphoma with the six-drug COP-BLAM regimen. Annals of 
    Internal Medicine.  97(2):190-5, 1982 Aug. 
  abstract...
    A new multiple-drug protocol consisting of cyclophosphamide, 
    vincristine, prednisone, bleomycin, doxorubicin, and 
    procarbazine, known as COP-BLAM, was administered to 48 
    patients with stage III or IV diffuse histiocytic lymphoma. 
    Twenty-four of the 33 previously untreated patients had a 
    complete remission, and eight patients had a partial response. 
    The median survival for all previously untreated patients has 
    not yet been reached at 23 months. Median survival for complte 
    responders has not yet been attained at 26 months, although 
    survival of partial responders is 12.5 months. There were no 
    patients with a complete response who had a central nervous 
    system relapse. The COP-BLAM therapy is an easily administered 
    outpatient program capable of inducing a high frequency of 
    durable complete remissions in advanced diffuse histiocytic 
    lymphoma, a malignancy formerly considered to have a poor 
    prognosis.