DD                                                  melanoma(104)
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  dacarbazine..... 800 mg/sqm IV every 3 weeks.
  actinomycin..... 1.2 mg/sqm IV every 3 weeks.
  FREQUENCY....... Specified above.

  reference...
    Hochster H.  Levin M.  Speyer J.  Dunleavy S.  Harris M.  
    Roses D.  Golomb F. Muggia F. Single-dose dacarbazine and 
    dactinomycin in advanced malignant melanoma. Cancer Treatment 
    Reports.  69(1):39-42, 1985 Jan. 
  abstract...
    Twenty-one patients with advanced malignant melanoma were 
    treated with dacarbazine at a dose of 800 mg/m2 as a single 
    infusion and dactinomycin at a dose of 1.2 mg/m2 every 3 
    weeks. Hematologic toxicity was mild and gastrointestinal 
    toxicity was tolerable. The response rate for evaluable 
    patients was 22%, which included both men and women with 
    visceral disease. Three of the four responses were complete. 
    Durations of response were 4, 6, 9, and 48+ months. We 
    conclude that dacarbazine can be safely and effectively given 
    as a single dose along with dactinomycin. The possibility that 
    this combination may be more effective than single agents in 
    obtaining complete responses in patients with visceral disease 
    must be explored further.