CA                                              mesothelioma(111)
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  cytoxan......... 400 mg/sqm IV on days 1 and 8 or 

                   alternatively, 1,000 mg/sqm IV day 1.
  adriamycin...... 40 mg/sqm IV on days 1 and 8 or 

                   alternatively, 45 mg/sqm IV on day 1.
  FREQUENCY....... Repeat cycle every 28 days.

                   Repeat alternative cycle every 21 days.


  reference...
    Antman KH.  Pomfret EA.  Aisner J.  MacIntyre J.  Osteen RT. 
    Greenberger JS. Peritoneal mesothelioma: natural history and 
    response to chemotherapy. Journal of Clinical Oncology.  
    1(6):386-91, 1983 Jun. 
  abstract...
    Twenty-three patients with malignant peritoneal mesothelioma 
    seen at the Dana Farber Cancer Institute and the University of 
    Maryland Cancer Center from 1968 to 1982 were studied to 
    assess the natural history of the disease and the efficacy of 
    current treatment. Asbestos exposure was reported by 57%. Of 
    18 patients receiving a doxorubicin-containing regimen, 14 had 
    measurable or evaluable disease. One complete response, four 
    partial responses and one regression (in a patient with 
    evaluable but not measurable disease) were observed, ranging 
    in duration from 6 to 36 months. A single patient remains 
    disease free for more than 36 months after subsequent 
    radiotherapy. Significant clotting abnormalities (including 
    disseminated intravascular coagulation, massive thrombosis, 
    fatal pulmonary emboli, Coombs-positive hemolytic anemia, and 
    phlebitis) occurred in 22% of the patients. Trends toward 
    decreased survival were observed for smokers, patients 
    presenting with ascites, and those with stage II-IV disease.