AC                                              mesothelioma(112)
 _________________________________________________________________
  adriamycin...... 50 mg/sqm IV day 1.
  cisplatin....... 50 mg/sqm IV day 1.
  FREQUENCY....... Repeat cycle every 3 weeks.

  reference...
    Zidar BL.  Pugh RP.  Schiffer LM.  Raju RN.  Vaidya KA. Bloom 
    RL.  Horne D.  Baker LH. Treatment of six cases of 
    mesothelioma with doxorubicin and cisplatin. Cancer.  
    52(10):1788-91, 1983 Nov 15. 
  abstract...
    Six patients with unresectable malignant mesothelioma were 
    treated with chemotherapy consisting of doxorubicin and 
    cisplatin every 3 weeks. One patient with paratesticular 
    mesothelioma metastatic to lungs entered complete remission 
    for 8 months; his disease has relapsed but he is alive 32 
    months after initiation of chemotherapy. One patient with 
    peritoneal mesothelioma achieved partial response for 12 
    months. Two patients with pleural mesothelioma achieved a 
    partial response of 5- and 6-month durations, respectively. 
    Two patients with pleural mesothelioma failed to respond to 
    this regimen. Thus, four of six patients responded to 
    doxorubicin-cisplatin chemotherapy. These preliminary results 
    merit further study and confirmation; future investigations of 
    cisplatin alone are necessary to better define the role of 
    this agent in mesothelioma.