cytoxan......... 600 mg/sqm IV day 1.
hexamethylmelami 150 mg/sqm/day orally from day 8 to day 22.
adriamycin...... 25 mg/sqm IV day 1.
cisplatin....... 50 mg/sqm IV day 1.
FREQUENCY....... Repeat cycle every 28 days.
Vogl SE. Pagano M. Kaplan BH. Greenwald E. Arseneau J.
Bennett B. Cis-platin based combination chemotherapy for
advanced ovarian cancer. High overall response rate with
curative potential only in women with small tumor burdens.
Cancer. 51(11):2024-30, 1983 Jun 1.
Thirty-eight women with advanced ovarian cancer were given
monthly cycles of intravenous cyclophosphamide, Adriamycin
(doxorubicin) and cis-platin, and oral hexamethylmelamine. Of
26 with tumor which would be evaluated for response, 42% had
complete remission and 50% partial remission. Median time to
disease progression from entry for all 38 patients was 13
months, and median survival 23.5 months. The bulk of tumor at
the time chemotherapy was begun was the only significant
prognostic factor for time to disease progression and
survival. Of the seven women surviving free of disease a
median of three years later, five had no mass greater than 2
centimeters in diameter at entry. Toxicity was predominantly
myelosuppression and vomiting, with mild peripheral neuropathy
in 27% and no significant renal or cardiac toxicity. The
response rate of 92% is much higher than that previously
reported with melphalan, and the survival considerably longer.
The toxicity is acceptable, given the substantial improvement