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Cancer Chemotherapy Regimen for Ovarian Cancer


 IP-CC                                                ovarian(117)
 _________________________________________________________________
  cisplatin....... 200 mg/sqm IP over 30 minutes.
  cytarabine...... 2,000 mg IP over 30 minutes.
  FREQUENCY....... Repeat cycle every 28 days.


  reference...
    Markman M.  Cleary S.  Lucas WE.  Howell SB. Intraperitoneal 
    chemotherapy with high-dose cisplatin and cytosine arabinoside 
    for refractory ovarian carcinoma and other malignancies 
    principally involving the peritoneal cavity. Journal of 
    Clinical Oncology.  3(7):925-31, 1985 Jul. 
  abstract...
    Sixty-two patients with refractory ovarian carcinoma or other 
    malignancies principally confined to the peritoneal cavity 
    were treated with an intraperitoneal combination chemotherapy 
    regimen consisting of cisplatin (100 mg/m2 or 200 mg/m2) and 
    cytosine arabinoside (4 X 10(-3) mol/L or 10(-2) mol/L). 
    Sodium thiosulfate was simultaneously administered 
    intravenously (IV) to protect against cisplatin-induced 
    nephrotoxicity. Sixteen of 52 evaluable patients demonstrated 
    evidence of a clinical response including 14 (36%) of 39 with 
    refractory ovarian carcinoma. Systemic toxicity was not severe 
    except for cisplatin-induced emesis and a single episode of 
    major renal insufficiency. Dose-limiting toxicity was bone 
    marrow suppression with cytosine arabinoside administered at 
    10(-2) mol/L. We conclude that combination intraperitoneal 
    therapy with high-dose cisplatin and cytosine arbinoside can 
    be safely administered with objective tumor responses observed 
    in patients with ovarian carcinoma refractory to front-line 
    chemotherapy and in occassional individuals with other 
    malignancies principally confined to the peritoneal cavity. 
 

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