FAM-S                                               pancreas(121)
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  fluorouracil.... 600 mg/sqm IV on days 1, 8, 29, and 36.
  adriamycin...... 30 mg/sqm IV on days 1, and 29.
  mitomycin....... 10 mg/sqm IV day 1.
  streptozotocin.. 400 mg/sqm IV on days 1, 8, 29, and 36.
  FREQUENCY....... Repeat cycles every 56 days (8 weeks).


  reference...
    Bukowski RM.  Schacter LP.  Groppe CW.  Hewlett JS.  Weick JK. 
     Livingston RB. Phase II trial of 5-fluorouracil, adriamycin, 
    mitomycin C, and streptozotocin (FAM-S) in pancreatic 
    carcinoma. Cancer.  50(2):197-200, 1982 Jul 15. 
  abstract...
    Twenty-five patients with unresectable and metastatic 
    pancreatic carcinoma were treated with the combination of 
    5-fluorouracil, Adriamycin, mitomycin C and streptozotocin 
    (FAM-S). Twelve of 25 patients responded (48%) and four 
    patients demonstrated stable disease. Median survival of all 
    patients was 6.75 months, and seven of 25 patients survived 
    more than 12 months. Hematologic toxicity was moderate, and 
    the predominant side effect recorded was nausea and vomiting 
    (80% patients). Combination chemotherapy in pancreatic 
    carcinoma may provide palliation and randomized trials are 
    warranted to confirm these results.