VAC                                                  sarcoma(132)
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  vincristine..... 3 mg/sqm IV on days 1 and 8.
  adriamycin...... 60 mg/sqm IV day 1.
  cytoxan......... 600 mg/sqm IV day 1.
  FREQUENCY....... Repeat cycle every 21 days for 9 cycles or 
                   until progression.


  reference...
    Brenner J.  Magill GB.  Wissel P.  Sordillo PP. Chemotherapy 
    of patients with advanced soft tissue sarcoma with use of DVA 
    (vindesine sulfate), adriamycin and cyclophosphamide (DAC). 
    Cancer.  52(7):1142-5, 1983 Oct 1. 
  abstract...
    Thirty-four patients with advanced soft tissue sarcoma were 
    treated with a three-drug combination including vindesine 
    sulfate (DVA), Adriamycin, and cyclophosphamide (DAC) (S9). 
    Thirty-one patients are evaluable of whom 23 were previously 
    untreated. Among the latter group there were six complete 
    responses (26%) and five partial responses (22%), for a major 
    response rate of 48%. No major responses were seen in the 
    eight previously treated patients. The median duration of 
    responses was 8 months. Leukopenia and peripheral neuropathy 
    were the major complications of treatment. Gastrointestinal 
    toxicity was mild. Adriamycin cardiotoxicity was seen in two 
    patients. Although the overall response rate to DAC is 
    comparable to that of other combinations, it may offer the 
    advantages of an increased complete response rate and less 
    gastrointestinal toxicity.