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5-fluorouracil, doxorubicin, and cisplatin (FAP) regimen

 
 

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Abstract: A phase II study of combined 5-fluorouracil, doxorubicin, and cisplatin in the treatment of advanced upper gastrointestinal adenocarcinomas.

In a phase II study of 67 patients with upper gastrointestinal carcinomas and measurable disease without previous chemotherapy, we have evaluated the combination of intensive course 5-fluorouracil (5-FU) (300 mg/m2/d for five days) doxorubicin (40 mg/m2 on day 1), and cisplatin (60 mg/m2 on day 1). Courses were repeated every 5 weeks. Among 26 patients with gastric carcinoma, a 50% regression rate was obtained with a median survival for all patients of 9 months. Among 29 patients with pancreatic carcinoma, the regression rate was 21% and the median survival was 4 months. Regressions were also observed in smaller numbers of patients with carcinomas of the gallbladder and ampulla of Vater, as well as in cholangiocellular carcinoma of the liver. Toxic reactions were usually clinically tolerable and consisted primarily of nausea, vomiting, stomatitis, diarrhea, leukopenia, and alopecia. Phase III studies are in progress to place the value of this experimental regimen into clinical perspective.

References

Moertel CG, Rubin J, O'Connell MJ, Schutt AJ, Wieand HS. A phase II study of combined 5-fluorouracil, doxorubicin, and cisplatin in the treatment of advanced upper gastrointestinal adenocarcinomas. J Clin Oncol; 4(7):1053-7 1986.

Regimen

5 - FU....... 300 mg/m2/d days 1-5
Doxorubicin....... 40 mg / M2 IV day 1
Cisplatin....... 60 mg / M2 IV day 1
FREQUENCY every 5 weeks.

     
  Summary Phase II study of combined 5FU, doxorubicin, and cisplatin for gastric cancer
  Regression Rate 50%
  Median Survival 9 months
  Toxicity Nausea, vomiting, stomatitis, diarrhea, leukopenia, and alopecia.
     
Article reviewed by:

Dr. Tamer Fouad, M.D.

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