Cancer Chemotherapy Regimen for Stomach Cancer
FAM gastric(60) _________________________________________________________________ fluorouracil.... 600 mg/sqm IV days 1, 8, 28, and 35. adriamycin...... 30 mg/sqm IV days 1 and 28. mitomycin....... 10 mg/sqm IV day 1. FREQUENCY....... Repeat cycle every 56 days. reference... MacDonald JS. Schein PS. Woolley PV. Smythe T. Ueno W. Hoth D. Smith F. Boiron M. Gisselbrecht C. Brunet R. Lagarde C. 5-Fluorouracil, doxorubicin, and mitomycin (FAM) combination chemotherapy for advanced gastric cancer. Annals of Internal Medicine. 93(4):533-6, 1980 Oct. abstract... Sixty-two patients with advanced measurable gastric cancer were treated with a combination chemotherapy program of 5-fluorouracil, doxorubicin, and mitomycin (FAM). Forty-two percent of patients achieved an objective partial response. The median duration of remission was 9 months and the median survival for responding patients, 12.5 months. The median survival for nonresponding patients was 3.5 months; all patients were dead by 8 months after initiation of therapy. The median survival of all 62 patients treated with FAM was 5.5 months. An analysis of possible prognostic variables including initial performance status, resectability of the primary gastric tumor, and histologic differentiation of the neoplasm failed to account for differences in patient response and survival. The FAM regimen was well tolerated, producing only moderate bone marrow suppression. These results show that patients with metastatic gastric cancer can be effectively palliated with FAM chemotherapy. The efficacy of this regimen should now be tested in patients with less advanced stages of this disease.
Are you a Doctor, Pharmacist, PA or a Nurse?
Join the Doctors Lounge online medical community
Editorial activities: Publish, peer review, edit online articles.
Ask a Doctor Teams: Respond to patient questions and discuss challenging presentations with other members.