fluorouracil.... 600 mg/sqm IV days 1, 8, 28, and 35.
adriamycin...... 30 mg/sqm IV days 1 and 28.
mitomycin....... 10 mg/sqm IV day 1.
FREQUENCY....... Repeat cycle every 56 days.
MacDonald JS. Schein PS. Woolley PV. Smythe T. Ueno W.
Hoth D. Smith F. Boiron M. Gisselbrecht C. Brunet R.
Lagarde C. 5-Fluorouracil, doxorubicin, and mitomycin (FAM)
combination chemotherapy for advanced gastric cancer. Annals
of Internal Medicine. 93(4):533-6, 1980 Oct.
Sixty-two patients with advanced measurable gastric cancer
were treated with a combination chemotherapy program of
5-fluorouracil, doxorubicin, and mitomycin (FAM). Forty-two
percent of patients achieved an objective partial response.
The median duration of remission was 9 months and the median
survival for responding patients, 12.5 months. The median
survival for nonresponding patients was 3.5 months; all
patients were dead by 8 months after initiation of therapy.
The median survival of all 62 patients treated with FAM was
5.5 months. An analysis of possible prognostic variables
including initial performance status, resectability of the
primary gastric tumor, and histologic differentiation of the
neoplasm failed to account for differences in patient response
and survival. The FAM regimen was well tolerated, producing
only moderate bone marrow suppression. These results show that
patients with metastatic gastric cancer can be effectively
palliated with FAM chemotherapy. The efficacy of this regimen
should now be tested in patients with less advanced stages of