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Cancer Chemotherapy Regimen for Stomach Cancer

 FAM                                                   gastric(60)
  fluorouracil.... 600 mg/sqm IV days 1, 8, 28, and 35.
  adriamycin...... 30 mg/sqm IV days 1 and 28.
  mitomycin....... 10 mg/sqm IV day 1.
  FREQUENCY....... Repeat cycle every 56 days.

    MacDonald JS.  Schein PS.  Woolley PV.  Smythe T.  Ueno W. 
    Hoth D.  Smith F.  Boiron M.  Gisselbrecht C.  Brunet R.  
    Lagarde C. 5-Fluorouracil, doxorubicin, and mitomycin (FAM) 
    combination chemotherapy for advanced gastric cancer. Annals 
    of Internal Medicine.  93(4):533-6, 1980 Oct. 
    Sixty-two patients with advanced measurable gastric cancer 
    were treated with a combination chemotherapy program of 
    5-fluorouracil, doxorubicin, and mitomycin (FAM). Forty-two 
    percent of patients achieved an objective partial response. 
    The median duration of remission was 9 months and the median 
    survival for responding patients, 12.5 months. The median 
    survival for nonresponding patients was 3.5 months; all 
    patients were dead by 8 months after initiation of therapy. 
    The median survival of all 62 patients treated with FAM was 
    5.5 months. An analysis of possible prognostic variables 
    including initial performance status, resectability of the 
    primary gastric tumor, and histologic differentiation of the 
    neoplasm failed to account for differences in patient response 
    and survival. The FAM regimen was well tolerated, producing 
    only moderate bone marrow suppression. These results show that 
    patients with metastatic gastric cancer can be effectively 
    palliated with FAM chemotherapy. The efficacy of this regimen 
    should now be tested in patients with less advanced stages of 
    this disease. 

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