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Cancer Staging Systems

Staging of Chronic Lymphocytic Leukemia (CLL)

Rai staging System

Stage 0
Stage 0 chronic lymphocytic leukemia: absolute lymphocytosis (>15,000 per cubic millimeter) without adenopathy, hepatosplenomegaly, anemia, or thrombocytopenia.

Stage I
Stage I chronic lymphocytic leukemia: absolute lymphocytosis with lymphadenopathy without hepatosplenomegaly, anemia, or thrombocytopenia.

Stage II
Stage II chronic lymphocytic leukemia: absolute lymphocytosis with either hepatomegaly or splenomegaly, with or without lymphadenopathy.

Stage III
Stage III chronic lymphocytic leukemia: absolute lymphocytosis and anemia (hemoglobin <11 g/dL) with or without lymphadenopathy, hepatomegaly, or splenomegaly.

Stage IV
Stage IV chronic lymphocytic leukemia: absolute lymphocytosis and thrombocytopenia (<100,000 per cubic millimeter) with or without lymphadenopathy, hepatomegaly, splenomegaly, or anemia.

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Binet classification

Clinical stage A: no anemia or thrombocytopenia and fewer than three areas of lymphoid involvement (Rai stages 0, I, and II)

Clinical stage B: no anemia or thrombocytopenia with three or more areas of lymphoid involvement (Rai stages I and II)*

Clinical stage C: anemia and/or thrombocytopenia regardless of the number of areas of lymphoid enlargement (Rai stages III and IV)

References

1. Rai KR, Sawitsky A, Cronkite EP, et al.: Clinical staging of chronic lymphocytic leukemia. Blood 46 (2): 219-34, 1975.
2. Binet JL, Auquier A, Dighiero G, et al.: A new prognostic classification of chronic lymphocytic leukemia derived from a multivariate survival analysis. Cancer 48 (1): 198-206, 1981.

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