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Cancer Staging Systems

Staging of endometrial cancer

Last Update: Sunday January 4th, 2004 7:15 PM GMT

Stage grouping

Stage I

Stage I endometrial cancer is carcinoma confined to the corpus uteri.

  • Stage IA: tumor limited to endometrium.
  • Stage IB: invasion to less than one half of the myometrium.
  • Stage IC: invasion to greater than one half of the myometrium.

Stage II

Stage II endometrial cancer involves the corpus and the cervix, but has not extended outside the uterus.

  • Stage IIA: endocervical glandular involvement only.
  • Stage IIB: cervical stromal invasion.

Stage III

Stage III endometrial cancer extends outside of the uterus but is confined to the true pelvis.

  • Stage IIIA: tumor invades serosa and/or adnexa and/or positive peritoneal cytology.
  • Stage IIIB: vaginal metastases.
  • Stage IIIC: metastases to pelvic and/or para-aortic lymph nodes.

Stage IV

Stage IV endometrial cancer involves the bladder or bowel mucosa or has metastasized to distant sites.

  • Stage IVA: tumor invasion of bladder and/or bowel mucosa.
  • Stage IVB: distant metastases, including intra-abdominal and/or inguinal lymph nodes.

Endometrial cancer can be grouped with regard to the degree of differentiation of the adenocarcinoma, as follows:

  • G1: 5% or less of a nonsquamous or nonmorular solid growth pattern.
  • G2: 6% to 50% of a nonsquamous or nonmorular solid growth pattern.
  • G3: more than 50% of a nonsquamous or nonmorular solid growth pattern.

FIGO staging for endometrial cancer

  • Stage IA G123: tumor limited to endometrium.
  • Stage IB G123: invasion to less than one half the myometrium.
  • Stage IC G123: invasion to more than one half the myometrium.
  • Stage IIA G123: endocervical glandular involvement only.
  • Stage IIB G123: cervical stromal invasion.
  • Stage IIIA G123:tumor invades serosa and/or adnexa, and/or positive peritoneal cytology.
  • Stage IIIB G123:vaginal metastases.
  • Stage IIIC G123:metastases of pelvic and/or para-aortic lymph nodes.
  • Stage IVA G123: tumor invasion of bladder and/or bowel mucosa.
  • Stage IVB: distant metastases including intra-abdominal and/or inguinal lymph nodes.

References

  1. FIGO staging for corpus cancer. Br J Obstet Gynaecol 99(5): 440, 1992.
  2. Corpus uteri. In: American Joint Committee on Cancer.: AJCC Cancer Staging Manual. 5th ed. Philadelphia, Pa: Lippincott-Raven Publishers, 1997, pp 195-200. 

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