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Forum Name: Pediatric Topics

Question: 13 mo allergic to glycerine (glycerol)


 rothman1130 - Sun Oct 23, 2005 11:01 pm

I had my 13 mo old daughter tested fro allergies after she went to the hospital with hives and sweeling after dinner one night. nothing that she tested for on the scratch test popped op positive except for the negative controll- glycerine. when the allergist retested the control my daughter went into anaphylaxis and they had to give her 2 shots of epenepherine to counter react it. i keep hearing that it is impossible to be allergic to this and the allergists is baffeled! doin some research i have found that it is possible, but i am at a dead end and i need help- any information or suggestions? thank you for you time!
 dlugose - Wed Oct 26, 2005 5:46 pm

I'm surprised but some sites on the web say you can be allergic to glycerine, see
dermatitis.html" class="postlink">http://www.allergyescape.com/dermatitis.html

http://www.oldwestport.com/allergy/chemical_allergy.php
Other names for Glycerin are 1,2,3-Propanetriol and 1,2,3-Trihydroxypropane

Generally the immune system reacts to large molecules like proteins, much bigger than glycerine, but at
http://www.jcaai.org/pp/dh_3_classification.asp it says "Contact dermatitis is the typical immune response observed after topical exposure to a number of fatty vehicles and essential oils in therapeutic products (lanolin, clove oil, camphor oil, and beeswax). Any single or mixed variety of immune responses may occur after exposure to low molecular mass (1,000 daltons) inorganic or organic medicinal chemicals. The immunogenic potential of such drugs is often determined by one or more reactive end products or metabolites which haptenate with various body proteins. Often, the parent compound itself is not immunogenic because it lacks the ability to conjugate with proteins in a stable covalent linkage. Metabolism of drugs by cytochrome oxidase pathways may occur in the liver, skin, and phagocytic cells. In addition, patients with certain genetic polymorphisms are at higher risk for allergic and autoimmune disorders induced by drugs."
Sorry, but I don't know enough immulology and biochemistry to help much further. Basicly,Glycerine by itself occurs normally in the body and is too small alone to upset the immune system; perhaps it combines in some circumstances with something else and the two cause an allergy.
I sugest you learn all about glycerine by reading http://en.wikipedia.org/wiki/Glycerin
 rothman1130 - Thu Oct 27, 2005 2:27 am

thank you for thoughts- our allergist is going on to look at the possibility of food protein induced enterocolitits syndrome. do you perhaps have any thoughts on that? i have researched it a bit on my own and my daughter doesn't really seem to fit the symptoms, maybe i am over looking something. it was also suggested to me that i should have her tested for hypoclycemia and/or didabetes. again- we are stumped and just looking to see if we can find the problem!
 dlugose - Thu Oct 27, 2005 8:55 am

I'm glad an allergist is looking into it. What state do you live in? In different states they test newborns for different characteristics, mostly genetic, that often have something to do with enzymes and ability to digest various substances. That would be a list of conditions already ruled out, and there might be more of these mostly rare conditions that could be tested for. Sometimes they do not show themselves as problems in early infancy. Do you also have a list of things they tested for in the scratch testing?
Also question relatives about whether any blood relatives ever had digestive problems as infants or children, both your family and husbands'.

Ask lots of questions of doctor and take notes, and if you forget to ask something, ask the doctors nurse afterwards, or call and see if at his leisure he can have someone get back to you with an answer. I don't have time today to look more into protein induced enterocolitis syndrome, and I might soon get deployed to the Gulf area in Red Cross relief work.
 rothman1130 - Thu Oct 27, 2005 10:35 am

they tested for milk, soy, and eggs on the scratch test and blood test and they all came back negative. the allergists wants to do more scratch test, but i am scared to since she had such a bad reaction last time. we live in washington right now- do you know where i could find a list of things they could test for? i was looking at different autoimmune dieseases; they run in our family. and thank you once again for your help and i just wanted to say god bless you for going down to the gulf to help- that is where we are from and we have family that was effected by the hurricane. i think it is great. thank you again
 dlugose - Thu Oct 27, 2005 3:55 pm

Do you mean you live in Washington DC? The district does not test for as many things as VA or MD. See report and list of states at http://www.marchofdimes.com/peristats/whatsnew.aspx?id=2 I don't know of any particular disease this could be, not my field at all. go to google.com and search with this phrase exactly: site:http://www.allergicchild.com hives food
that will show you various pages at http://www.allergicchild.com that deal with hives from food.

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