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Forum Name: Pharmacy & Drug Topics

Question: Erythromycin and Zopiclone


 toothhurty - Sun Jul 25, 2010 3:35 pm

Im a taker of Zopiclone 7.5mg and was given Erythromycin 500mg from the dentist, i found out that Erythromycin magnifize the Zopiclone plasma levels to 80%, as ive not started to take Erythromycin yet would it be safe to..
 Dr.M.jagesh kamath - Tue Jul 27, 2010 2:44 am

User avatar Hello,You are right in that erythromycin does increase plasma zopiclone levels.Br J clin Pharmac 1994; 38: 363-367
The effect of erythromycin on the pharmacokinetics and
pharmacodynamics of zopiclone
The authors here conclude that it leads to faster hypnotic effects of zopiclone when used as a combination.They conclude that zopicone is safer with macrolide like erythromycin than other short acting hypnotics like triazolam.They say these results may not be applicable for older patients,and who are on other drugs affecting the CNS.
You can always call on your dental surgeon to make sure.May be he may choose another antibiotic, if you still need it.
Best wishes.

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