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Forum Name: Pharmacology Topics

Question: Can Zoloft make anxiety worse?

pennycandy1 - Wed Sep 03, 2003 6:32 pm

I was experiencing moderate, occasional Anxiety, taking Xanax .25 as needed (once daily). My OB/Gyne started me on Zoloft 2 weeks ago and the Anxiety has gotten much worse. Can a side effect of Zoloft be increased Anxiety?

Dr. Tamer Fouad - Wed Sep 03, 2003 9:27 pm

Pennycandy1, Sertraline (Zoloft) may indeed cause agitation, Anxiety and nervousness. It occurs in 1-10% of patients taking the Antidepressant. Its to be noted that the use of Zoloft in the treatment of Anxiety disorder is investigational as far as I know. Its mainly used for the treatment of major Depression, OCD, Panic disorder and postraumatic stress disorder. Best to consult with a neurologist on this issue. Best regards,

pennycandy1 - Thu Sep 04, 2003 4:54 am

Thank you so much for the info. Will I have any problems if I stop the Zoloft abruptly? This past week has been awful. Again, thank you kindly for the quick reply.

Dr. Tamer Fouad - Thu Sep 04, 2003 10:26 pm

Stopping abruptly is not a good idea. It can cause rebound symptoms leading to Depression, more Anxiety and insomnia. Best consult with your physcian on this preferrably and neuropsychiatrist. My best wishes to you.

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