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The Doctors Lounge - Primary Care Answers

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Forum Name: Miscellaneous Student Topics

Question: henoch-schoenlein

Anonymous - Fri May 02, 2003 4:29 pm

Im doing a report for a physio class and was wondering if anyone could tell me how immunoglobulin A is responsible for the onset of Henoch-Schoenlein purpura. Thanks! :)
a_medico - Sat May 03, 2003 1:15 am

Allergen(drugs, food, insect bite, intection, vaccination etc)##> stimulation##>elevated IgA levels -> IgA-mediated vasculitis in small vessels of involved organs -> necrotizing vasculitis##>HENOCH-SCHOENLEIN PURPURA

Mechanism of vasulitis:-
*deposition of IgA-containing immune complexes with subsequent activation of complement leads to a vasculitis
*biopsy of an acute skin lesion reveals an aseptic vasculitis with fibrinoid necrosis of vessel walls and perivascular cuffing of vessels

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