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Back to Drug index
Name: Leucovorin calcium
Pregnancy Category C
Drug classes
Folic acid derivative
Therapeutic actions
Active reduced form of folic acid; required for nucleoprotein
synthesis and
maintenance of normal erythropoiesis.
Indications
"Leucovorin rescue"-after high-dose methotrexate therapy in
osteosarcoma
Treatment of megaloblastic anemias due to sprue, nutritional
deficiency,
pregnancy, and infancy when oral folic acid therapy is not
feasible-parenteral form
With 5-fluorouracil for palliative treatment of metastatic colorectal
cancer
Contraindications/cautions
Allergy to leucovorin on previous exposure, pernicious anemia or other
megaloblastic anemias in which vitamin B12 is deficient, lactation
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Adverse effects
- Hypersensitivity: Allergic reactions
- Local: Pain and discomfort at injection site
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