Back to Psychiatry Drug Index
Name: Buspirone Hydrochloride
Pregnancy Category B
Mechanisms of action
Mechanism of action not known; lacks anticonvulsant, sedative, or
relaxant properties; binds serotonin receptors, but the clinical
significance of this is not known.
- Management of anxiety disorders or short-term relief of symptoms of
- Unlabeled use: decreasing the symptoms (aches, pains, fatigue, cramps,
irritability) of premenstrual syndrome (PMS)
- Hypersensitivity to buspirone; marked liver or renal impairment;
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- CNS: Dizziness, headache, nervousness, insomnia, lightheadedness,
excitement, dream disturbances, drowsiness, decreased concentration,
anger, hostility, confusion, depression, tinnitus, blurred vision,
numbness, paresthesia, incoordination, tremor, depersonalization,
dysphoria, noise intolerance, euphoria, akathisia, fearfulness, loss
interest, disassociative reaction, hallucinations, suicidal ideation,
seizures, altered taste and smell, involuntary movements, slowed
- GI: Nausea, dry mouth, vomiting, abdominal/gastric distress, diarrhea,
constipation, flatulence, anorexia, increased appetite, salivation,
irritable colon and rectal bleeding
- CV: Nonspecific chest pain, tachycardia/palpitations, syncope,
- Respiratory: Hyperventilation, shortness of breath, chest congestion
- GU: Urinary frequency, urinary hesitancy, dysuria, increased or
decreased libido, menstrual irregularity, spotting
- Other: Musculoskeletal aches and pains, sweating, clamminess, sore
throat, nasal congestion