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Back to Psychiatry Drug Index

Back to Antianxiety drugs

Name: Buspirone Hydrochloride

Pregnancy Category B

Drug classes

  • Antianxiety agent

Mechanisms of action

Mechanism of action not known; lacks anticonvulsant, sedative, or muscle relaxant properties; binds serotonin receptors, but the clinical significance of this is not known.


  • Management of anxiety disorders or short-term relief of symptoms of anxiety
  • Unlabeled use: decreasing the symptoms (aches, pains, fatigue, cramps, irritability) of premenstrual syndrome (PMS)


  • Hypersensitivity to buspirone; marked liver or renal impairment; lactation.
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Adverse effects

  • CNS: Dizziness, headache, nervousness, insomnia, lightheadedness, excitement, dream disturbances, drowsiness, decreased concentration, anger, hostility, confusion, depression, tinnitus, blurred vision, numbness, paresthesia, incoordination, tremor, depersonalization, dysphoria, noise intolerance, euphoria, akathisia, fearfulness, loss of interest, disassociative reaction, hallucinations, suicidal ideation, seizures, altered taste and smell, involuntary movements, slowed reaction time
  • GI: Nausea, dry mouth, vomiting, abdominal/gastric distress, diarrhea, constipation, flatulence, anorexia, increased appetite, salivation, irritable colon and rectal bleeding
  • CV: Nonspecific chest pain, tachycardia/palpitations, syncope, hypotension, hypertension
  • Respiratory: Hyperventilation, shortness of breath, chest congestion
  • GU: Urinary frequency, urinary hesitancy, dysuria, increased or decreased libido, menstrual irregularity, spotting
  • Other: Musculoskeletal aches and pains, sweating, clamminess, sore throat, nasal congestion

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