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Back to Psychiatry Drug Index

Back to Serotinine Reuptake Inhibitors

Name: Fluoxetine hydrochloride

Pregnancy Category C

Drug classes of Fluoxetine

Mechanism of action of Fluoxetine

Acts by inhibiting CNS neuronal uptake of serotonin leading to increased levels of serotonin in the brain. It has little effect on norepinephrine and dopamine.

Indications of Fluoxetine

Treatment of depression; most effective in patients with major depressive disorder

Unlabeled uses: treatment of obesity, treatment of bulimia and obsessive-compulsive disorders

Contraindications of Fluoxetine

Concomitant use in patients taking monoamine oxidase inhibitors (MAOIs) is contraindicated.

Contraindicated in the presence of hypersensitivity to fluoxetine; pregnancy.

Caution in the presence of impaired hepatic or renal function, diabetes mellitus, lactation.

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Adverse effectsof Fluoxetine


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