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Back to Psychiatry Drug Index
Name: Nefazodone hydrochloride
Pregnancy Category C
Drug classes of Nefazodone
Mechanism of action of Nefazodone
Acts by inhibiting CNS neuronal uptake of serotonin and norepinephrine;
also blocks 5-HT2 and apha1 receptors. The drug has no significant
affinity for alpha1, beta-adrenergic, 5-HT1A, cholinergic,
dopaminergic or benxodiazipine receptors.
Indications
of Nefazodone
Treatment of
depression
Contraindications of Nefazodone
- Contraindicated in the presence of hypersensitivity to
nefazodone; related compounds (phenylpiperazines).
- Contraindicated in the presence of impaired hepatic or renal
function.
- Should not be taken concurrently with
MAO inhibitors.
MAO inhibitors can
only be initiated 7 days after discontinuation of serotonin reuptake
inhibitors.
- Concurrent use with astemizole, carbamazipine, cisapride or
pimozide, triazolam or alprazolam.
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Adverse effectsof Nefazodone
-
CNS:
Headache, nervousness, insomnia,
drowsiness, anxiety, dizziness, agitation
-
GI:
Nausea, xerostomia,
constipation
-
CV:
Bradycardia, hypotension,
peripheral edema, palpitations
-
Endocrine: Breast pain, decreased
libido,
impotence
- Neuromuscular & skeletal:
Weakness
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