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Back to Psychiatry Drug Index

Back to Serotinine Reuptake Inhibitors

Name: Nefazodone hydrochloride

Pregnancy Category C

Drug classes of Nefazodone

Mechanism of action of Nefazodone

Acts by inhibiting CNS neuronal uptake of serotonin and norepinephrine; also blocks 5-HT2 and apha1 receptors. The drug has no significant affinity for alpha1, beta-adrenergic, 5-HT1A, cholinergic, dopaminergic or benxodiazipine receptors.

Indications of Nefazodone

Treatment of depression

Contraindications of Nefazodone

  • Contraindicated in the presence of hypersensitivity to nefazodone; related compounds (phenylpiperazines).
  • Contraindicated in the presence of impaired hepatic or renal function.
  • Should not be taken concurrently with MAO inhibitors. MAO inhibitors can only be initiated 7 days after discontinuation of serotonin reuptake inhibitors.
  • Concurrent use with astemizole, carbamazipine, cisapride or pimozide, triazolam or alprazolam.
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Adverse effectsof Nefazodone

  • CNS: Headache, nervousness, insomnia, drowsiness, anxiety, dizziness, agitation
  • GI: Nausea, xerostomia, constipation
  • CV: Bradycardia, hypotension, peripheral edema, palpitations
  • Endocrine: Breast pain, decreased libido, impotence
  • Neuromuscular & skeletal: Weakness

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