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Name: Serzone hydrochloride
Pregnancy Category C
Drug classes of Serzone
Mechanism of action of Serzone
Acts by inhibiting CNS neuronal uptake of serotonin and norepinephrine;
also blocks 5-HT2 and apha1 receptors. The drug has no significant
affinity for alpha1, beta-adrenergic, 5-HT1A, cholinergic,
dopaminergic or benxodiazipine receptors.
Contraindications of Serzone
- Contraindicated in the presence of hypersensitivity to
Serzone; related compounds (phenylpiperazines).
- Contraindicated in the presence of impaired hepatic or renal
- Should not be taken concurrently with
MAO inhibitors can
only be initiated 7 days after discontinuation of serotonin reuptake
- Concurrent use with astemizole, carbamazipine, cisapride or
pimozide, triazolam or alprazolam.
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Adverse effectsof Serzone
Headache, nervousness, insomnia,
drowsiness, anxiety, dizziness, agitation
peripheral edema, palpitations
Endocrine: Breast pain, decreased
- Neuromuscular & skeletal: