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Back to Psychiatry Drug Index
Brand Name: Zoloft
Name: Sertraline hydrochloride
Pregnancy Category C
Drug classes
Mechanism of action of Zoloft
Acts as an antidepressant by inhibiting CNS neuronal uptake of serotonin;
which raises serotonin levels in the CNS with little effect on norepinephrine,
muscarinic, histaminergic, and alpha1-adrenergic or dopaminergic receptors.
Indications of Zoloft
Treatment of
depression
Unlabeled use: treatment of
obsessive-compulsive
disorders
Contraindications of Zoloft
Should not be taken concurrently with
MAO inhibitors.
MAO inhibitors can
only be initiated 7 days after discontinuation of serotonin reuptake
inhibitors.
Contraindicated in the presence of hypersensitivity to Zoloft; pregnancy.
Use caution in the presence of impaired hepatic or renal function, lactation.
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Adverse effectsof Zoloft
-
CNS:
Headache, nervousness, drowsiness,
anxiety, tremor, dizziness, insomnia lightheadedness, agitation, sedation,
abnormal gait, convulsions, vision changes, fatigue
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GI:
Nausea,
vomiting,
diarrhea, dry
mouth, anorexia, dyspepsia,
constipation,
taste changes, flatulence, gastroenteritis,
dysphagia, gingivitis
-
CV: Palpitations,
chest
pain
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Respiratory: Upper respiratory infections,
pharyngitis,
cough,
dyspnea,
bronchitis, rhinitis
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GU: Painful menstruation, sexual dysfunction,
frequency, cystitis,
impotence, urgency, vaginitis
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Dermatologic: Sweating, rash,
pruritus,
acne,
contact dermatitis
-
Other: Hot flushes,
fever,
back pain,
thirst
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