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Back to Psychiatry Drug Index

Back to Serotinine Reuptake Inhibitors

Brand Name: Zoloft
Name: Sertraline hydrochloride

Pregnancy Category C

Drug classes

Mechanism of action of Zoloft

Acts as an antidepressant by inhibiting CNS neuronal uptake of serotonin;
which raises serotonin levels in the CNS with little effect on norepinephrine, muscarinic, histaminergic, and alpha1-adrenergic or dopaminergic receptors.

Indications of Zoloft

Treatment of depression

Unlabeled use: treatment of obsessive-compulsive disorders

Contraindications of Zoloft

Should not be taken concurrently with MAO inhibitors. MAO inhibitors can only be initiated 7 days after discontinuation of serotonin reuptake inhibitors.

Contraindicated in the presence of hypersensitivity to Zoloft; pregnancy.

Use caution in the presence of impaired hepatic or renal function, lactation.

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Adverse effectsof Zoloft


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