Back to Psychiatry Drug Index
Brand Name: Zoloft
Name: Sertraline hydrochloride
Pregnancy Category C
Mechanism of action of Zoloft
Acts as an antidepressant by inhibiting CNS neuronal uptake of serotonin;
which raises serotonin levels in the CNS with little effect on norepinephrine,
muscarinic, histaminergic, and alpha1-adrenergic or dopaminergic receptors.
Indications of Zoloft
Unlabeled use: treatment of
Contraindications of Zoloft
Should not be taken concurrently with
MAO inhibitors can
only be initiated 7 days after discontinuation of serotonin reuptake
Contraindicated in the presence of hypersensitivity to Zoloft; pregnancy.
Use caution in the presence of impaired hepatic or renal function, lactation.
Are you a doctor or a nurse?
Do you want to join the Doctors Lounge online medical community?
Participate in editorial activities (publish, peer review, edit) and
give a helping hand to the largest online community of patients.
Click on the link below to see the requirements:
Doctors Lounge Membership
Adverse effectsof Zoloft
Headache, nervousness, drowsiness,
anxiety, tremor, dizziness, insomnia lightheadedness, agitation, sedation,
abnormal gait, convulsions, vision changes, fatigue
mouth, anorexia, dyspepsia,
taste changes, flatulence, gastroenteritis,
Respiratory: Upper respiratory infections,
GU: Painful menstruation, sexual dysfunction,
impotence, urgency, vaginitis
Dermatologic: Sweating, rash,
Other: Hot flushes,