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Doctors Lounge - Psychiatry Answers
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| pain in the sunshine stat
- Wed Dec 14, 2005 1:39 pm |
|
Hello,
I have been on Effexor XR for over a year I am taking 225 mg, my diet has not changed and I am active. I do not have a routine excercise plan, but I never had one either. I have blown up in my belly midsection. Can Wellbutrin by perscribed with Effexor XR?
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| Dr. Tamer Fouad
- Thu Dec 15, 2005 1:12 am |
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 Venlafaxine (Effexor), a potent inhibitor of serotonin and norepinephrine reuptake, is sometimes prescribed for patients with psychomotor retardation, hypersomnia, or resistance to other antidepressants.[1] A short-term study comparing venlafaxine (Effexor) with fluoxetine (Prozac) found no significant weight gain with either agent.[2] Thus, like SSRIs and unlike mirtazapine, venlafaxine (Effexor) is less likely to cause weight gain in the short term,[3] although there are not enough data to comment on its long-term effects.
You will need to discuss the possibility of changing your medication with your psychiatrist.
References:
===========
1. Stahl SM. Psychopharmacology of antidepressants. London, UK: Dunitz 1998.
2. Silverstone PH, Ravindran A. Once daily venlafaxine extended release compared with fluoxetine in outpatients with depression and anxiety. Venlafaxine XR 360 Study Group. J Clin Psychiatry 1999; 60:22–28.
3. Guelfi JD, Ansseau M, Timmerman L, Korsgaard S. Mirtazapine vs venlafaxine in hospitalized severely depressed patients with melancholic features. Mirtazapine-Venlafaxine Study Group. J Clin Psychopharmacol 2001; 21:425–431.
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