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Forum Name: Psychiatric Topics

Question: Is it ok to mix 5-HTP with Zoloft ?

 Bru023 - Tue Mar 25, 2008 10:07 pm

From my understanding 5-HTP is a supplement that that our body uses to create seritonin and zoloft works by blocking Seritonin from reentering the nerve ending increasing function . would I be wrong to take both at the same time? wouldnt that optimize the performance or would i be at risk for seritonin poising ?
 R. Zein, Pharm D - Thu Mar 27, 2008 8:17 pm

User avatar Dear bru 023

Since 5-HTP (or tryptophan) is converted to serotonin, it would be unwise to administer tryptophan or 5-HTP in combination with SSRIs (eg zoloft) or any other agents that would potentially increase serotonin. Too much serotonin can indeed lead to a serious but rare condition known as "serotonin syndrome". Therefore, I would recommend that you only take zoloft, especially that 5-HTP Is available as dietary supplement and it is not regulated by FDA as drug.

With supplements, one should be careful because rigid quality control standards are not required and substantial variability can occur in both the potency and the purity of these products.

thank you very much and remain blessed


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