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Forum Name: Antidepressants

Question: Mixing antidepressants


 tam - Sun Nov 07, 2004 8:13 pm

I really need HELP!!!!
I need to know the effects of mixing trazadone with imipramine?
PLEASE SOMEONE ANSWER
 DeLWolcott - Wed Oct 05, 2005 4:44 pm

imipramine and trazodone (major Drug-Drug)
Description:
MONITOR CLOSELY: Concomitant use of agents with serotonergic activity such as
serotonin reuptake inhibitors, monoamine oxidase inhibitors, tricyclic antidepressants, 5-HT1 receptor agonists, ergot alkaloids, lithium, St. John's wort, phenylpiperidine opioids, dextromethorphan, and 5-hydroxytryptophan may potentiate the risk of serotonin syndrome, which is a rare but serious and potentially fatal condition thought to result from hyperstimulation of brainstem 5-HT1A receptors.
MANAGEMENT:
In general, the concomitant use of multiple serotonergic agents should be avoided if possible, or otherwise approached with caution if potential benefit is deemed to outweigh the risk. Close monitoring is recommended for signs and symptoms of excessive serotonergic activity such as CNS irritability, altered consciousness, confusion, myoclonus, ataxia, abdominal cramping, hyperpyrexia, shivering, pupillary dilation, diaphoresis, hypertension, and tachycardia. Particular caution is advised when increasing the dosages of these agents.

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