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Hydrocodone bitartrate

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Pregnancy Category C

Drug classes
Narcotic agonist analgesic

Mechanism of action of Hydrocodone
Acts at opioid receptors in the CNS to produce analgesia, euphoria, sedation; acts in medullary cough center to depress cough reflex.

Indications of Hydrocodone

1. Suppresses cough reflex by direct action on cough center in the medulla.
2. Available only in combination products.

Contraindications of Hydrocodone

Use caution in the presence of pregnancy, labor, lactation, bronchial asthma, COPD, respiratory depression, anoxia, increased intracranial pressure, debilitation, postoperative state.

Adverse effects of Hydrocodone

• CNS: Sedation, clamminess, sweating, headache, vertigo, floating
  feeling, dizziness, lethargy, confusion, lightheadedness
• GI: Dry mouth, anorexia, constipation, nausea, biliary tract spasm
• Dermatologic: Rash, hives, pruritus, flushing, warmth, sensitivity to
  cold

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