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Brand Name: Brufen
Name: Ibuprofen

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Pregnancy Category B

Drug classes
Antipyretic
NSAID Analgesic

Mechanism of action of Brufen
Anti-inflammatory, analgesic, and antipyretic activities largely related to inhibition of prostaglandin synthesis; exact mechanisms of action are not known.

Indications of Brufen

1. Relief of signs and symptoms of rheumatoid arthritis and osteoarthritis
2. Relief of mild to moderate pain
   Treatment of primary dysmenorrhea
3. Fever reduction
4. Unlabeled use: treatment of juvenile rheumatoid arthritis

Contraindications of Brufen

1. Presence of allergy to ibuprofen, salicylates, or other NSAIDs (more common in patients with rhinitis, asthma, chronic urticaria, nasal polyps)
2. Cardiovascular dysfunction
3. Hypertension
4. Peptic ulceration
5. GI bleeding
6. Pregnancy
7. Lactation

Use caution in the presence of impaired hepatic or renal function.

Adverse effects of Brufen

• CNS: Headache, dizziness, somnolence, insomnia, fatigue, tiredness, dizziness, tinnitus, ophthalmologic effects
• GI: Nausea, dyspepsia, GI pain, diarrhea, vomiting, constipation, flatulence
• Respiratory: Dyspnea, hemoptysis, pharyngitis, bronchospasm, rhinitis
• Hematologic: Bleeding, platelet inhibition with higher doses, neutropenia, eosinophilia, leukopenia, pancytopenia, thrombocytopenia, agranulocytosis, granulocytopenia, aplastic anemia, decreased hemoglobin or hematocrit, bone marrow depression, menorrhagia
• GU: Dysuria, renal impairment
• Dermatologic: Rash, pruritus, sweating, dry mucous membranes, stomatitis
• Other: Peripheral edema, anaphylactoid reactions to fatal anaphylactic shock

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