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C-reactive protein
C-reactive protein (CRP) is a plasma protein, an acute phase protein
produced by the liver.
History and nomenclature
CRP was originally discovered by Tillett and Francis in 1930 as a
substance in the serum of patients with acute inflammation that
reacted with the C polypeptide of pneumococcus.
Function
CRP is a member of the class of acute phase reactants as its levels
rise dramatically during inflammatory processes occurring in the body.
Measuring and charting C-reactive protein values can prove useful in
determining disease progress or the effectiveness of treatments.
It is thought to assist in complement binding to foreign and damaged
cells and affect the humoral response to disease.
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Role in cardiovascular disease
Recent research suggests that patients with elevated basal levels of
CRP are at an increased risk for hypertension and cardiovascular
disease, although recent research suggests the correllation is
moderate.
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