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Wolf's Down and Dirty Lists


SIGNATURE DRUG TOXICITIES

Agranulocytosis Clozapine
Aplastic Anemia Chloramphenicol

NSAIDs

Benzene

Atropine-like Side Effects Tricyclics
Cardiotoxicity Doxorubicin

Daunorubicin

Cartilage Damage in children Fluoroquinolones (Ciprofloxacin & Norfloxacin)
Cinchonism Quinidine
Cough ACE Inhibitors
Diabetes Insipidus Lithium
Disulfiram-like effect Metronidazole

Sulfonylureas (1st generation)

Extrapyramidal Side Effects Antipsychotics (Thioridazine, Haloperidol, Chlorpromazine)
Fanconi's Syndrome Tetracycline
Fatal Hepatotoxicity (necrosis) Valproic Acid

Halothane

Acetaminophen

Gingical Hyperplasia Phenytoin
Gray Baby Syndrome Chloramphenicol
Gynecomastia Cimetidine

Azoles

Spironolactone

Digitalis

Hemolytic Anemia in G6PD-deficiency Sulfonamides

Isoniazid

Aspirin

Ibuprofen

Primaquine

Hepatitis Isoniazid
Hot Flashes, Flushing Niacin

Tamoxifen

Ca++ Channel Blockers

Induce CP450 Barbiturates

Phenytoin

Carbamazepine

Rifampin

Inhibit CP450 Cimetidine

Ketoconazole

Interstitial Nephritis Methicillin

NSAIDs (except Aspirin)

Furosemide

Sulfonamides

Monday Disease Nitroglycerin Industrial exposure ----> tolerance during week ----> loss of tolerance during weekend ----> headache, tach, dizziness upon re-exposure
Orange Body Fluids Rifampin
Osteoporosis Heparin

Corticosteroids

Positive Coombs' Test Methyldopa
Pulmonary Fibrosis Bleomycin

Amiodarone

Red Man Syndrome Vancomycin
Severe HTN with Tyramine MAOIs
SLE-like Syndrome Procainamide

Hydralazine

Tardive Dyskinesia Antipsychotics (Thioridazine, Haloperidol, Chlorpromazine)
Tinnitus Aspirin

Quinidine


Article reviewed by:

Dr. Tamer Fouad, M.D.

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