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Trospium chloride helps control symptoms of overactive bladder systemically
as well as when it comes into contact with the bladder
walls.
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A commonly prescribed incontinence drug may help patients
in more than one way, according to research completed by the
University of Pittsburgh. When taken orally, trospium
chloride not only helps control symptoms of overactive
bladder systemically, but according to this study, it also
may help control symptoms in the bladder itself when it
comes into contact with the bladder walls. Results of this
study are being presented today at the annual meeting of the
American Urological Association (AUA) in San Antonio, and
are published in abstract 542 in the AUA proceedings.
"When taken orally, certain classes of drugs can control the
muscle contractions that cause conditions like overactive bladder.
In this study, we have found one drug, trospium, reacts with the
bladder muscle as urine is stored in the bladder," said Michael
Chancellor, M.D., professor, department of urology, University of
Pittsburgh School of Medicine. "It is exciting to see that this drug
could be helping the same patients in more ways than we had
previously thought."
In the study, urine samples from human subjects taking the anti-muscarinic
drugs trospium, tolterodine LA and oxybutynin XL and from control
subjects were instilled into the bladders of animal models.
Researchers induced bladder overactivity using carbachol. The
trospium bladder did not react to the carbachol, indicating that the
trospium had a topical effect on controlling the muscle
contractions. In the control, tolterodine- and oxybutynin-treated
bladders, the length of time between bladder contractions and the
bladder's capacity were decreased – representing overactive
bladder-type conditions and indicating no topical effect.
Anti-muscarinic drugs block receptors in the bladder responsible
for smooth muscle contractions; by easing the muscle contractions,
the number of incontinence episodes are reduced and bladder capacity
is increased. Common urologic conditions like overactive bladder are
caused by involuntary contractions of the detrusor muscle, which
controls the bladder.
More than 17 million Americans suffer from overactive bladder, a
condition that significantly affects the patient's quality of life.
An estimated 80 percent of these patients do not seek help or
treatment for this condition. Overactive bladder is characterized by
the following conditions: frequency – urinating more than eight
times in a 24 hour period; urgency – the immediate and strong urge
to urinate; and urge incontinence – the inability to suppress
urgency, resulting in the leaking or loss of urine.
###
In addition to Dr. Chancellor, Yong Tae Kim, Hitoshi Masuda,
Fernando de Miguel, all from the University of Pittsburgh School of
Medicine, contributed to this study.
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