Pregnancy Category B
- Antihyperlipidemic agent
Inhibits peripheral lipolysis and decreases the hepatic excretion of free fatty acids; this reduces hepatic triglyceride production; inhibits synthesis of VLDL carrier apolipoprotein; decreases VLDL production; increases HDL concentration.
Hypertriglyceridemia in adult patients with triglyceride levels 750 mg/dl (type IVand V hyperlipidemia) at risk of abdominal pain and pancreatitis who do not respond to diet therapy
Reduction of coronary heart disease risk, possibly effective
Allergy to gemfibrozil, hepatic or renal dysfunction, primary biliary cirrhosis, gallbladder disease, pregnancy, lactation.
- CNS: Headache, dizziness, blurred vision, vertigo, insomnia, paresthesia, tinnitus, fatigue, malaise, syncope
- GI: Abdominal pain, epigastric pain, diarrhea, nausea, vomiting, flatulence, dry mouth, constipation, anorexia, dyspepsia, cholelithiasis
- Hematologic: Anemia, eosinophilia, leukopenia, hypokalemia, liver function changes, hyperglycemia
- GU: Impairment of fertility
- Dermatologic: Eczema, rash, dermatitis, pruritus, urticaria
- Other: Painful extremities, back pain, arthralgia, muscle cramps, myalgia, swollen joints
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