Pregnancy Category X
Drug classes of Lescol
Mechanism of action of Lescol
A fungal metabolite that inhibits the enzyme HMG-CoA that catalyzes the first step in the cholesterol synthesis pathway, resulting in a decrease in serum cholesterol, serum LDLs (associated with increased risk of coronary artery disease), and either an increase or no change in serum HDLs (associated with decreased risk of coronary artery disease).
Indications of Lescol
- As an adjunct to diet in the treatment of elevated total cholesterol and LDL cholesterol in patients with primary hypercholesterolemia (types IIa and IIb) whose response to dietary restriction of saturated fat and cholesterol and other nonpharmacologic measures has not been adequate.
Contraindications of Lescol
- Allergy to fluvastatin
- Fungal byproducts
Use caution in the presence of impaired hepatic function, cataracts.
Adverse effects of Lescol
Headache, blurred vision, dizziness, insomnia, fatigue, muscle cramps, cataracts
- GI: Flatulence,
- Hematologic: Elevations of CPK, alkaline phosphatase and transaminiases
- Neuromuscular: Myopathy, rhabdomyolysis
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