Pregnancy Category C
- Calcium channel-blocker
- Antianginal drug
Inhibits the movement of calcium ions across the membranes of cardiac and arterial muscle cells; inhibits transmembrane calcium flow, which results in the depression of impulse formation in specialized cardiac pacemaker cells, slowing of the velocity of conduction of the cardiac impulse, depression of myocardial contractility, and dilation of coronary arteries and arterioles and peripheral arterioles; these effects lead to decreased cardiac work, decreased cardiac energy consumption, and in patients with vasospastic (Prinzmetal's) angina, increased delivery of oxygen to cardiac cells.
- Angina pectoris due to coronary artery spasm (Prinzmetal's variant angina)
- Chronic stable angina, alone or in combination with other agents
- Essential hypertension, alone or in combination with other antihypertensives
Allergy to diltiazem, impaired hepatic or renal function, sick sinus syndrome, heart block (second or third degree), lactation.
- CNS: Dizziness, lightheadedness, headache, asthenia, fatigue, lethargy
- GI: Nausea, abdominal discomfort
- CV: Peripheral edema, arrhythmias
- Dermatologic: Flushing, rash
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