Pregnancy Category B
- Thiazide-like diuretic (actually an indoline)
Inhibits reabsorption of sodium and chloride in distal renal tubule, increasing excretion of sodium, chloride, and water by the kidney.
- Edema associated with CHF
- Hypertension, as sole therapy or in combination with other antihypertensives
Unlabeled use: diabetes insipidus, especially nephrogenic diabetes insipidus
Contraindicated in the presence of allergy to thiazides, sulfonamides; fluid or electrolyte imbalance; renal disease (risk of azotemia); liver disease (may precipitate hepatic coma); gout (risk of precipitation of attack); SLE; glucose tolerance abnormalities, diabetes mellitus; hyperparathyroidism; manic-depressive disorder (aggravated by hypercalcemia); pregnancy; lactation.
- CNS: Dizziness, vertigo, paresthesias, weakness, headache, drowsiness, fatigue, leukopenia, thrombocytopenia, agranulocytosis, aplastic anemia, neutropenia
- GI: Nausea, anorexia, vomiting, dry mouth, diarrhea, constipation,
jaundice, hepatitis, pancreatitis
CV: Orthostatic hypotension, venous thrombosis, volume depletion, cardiac arrhythmias, chest pain
- GU: Polyuria, nocturia, impotence, loss of libido
- Dermatologic: Photosensitivity, rash, purpura, exfoliative dermatitis, hives
- Other: Muscle cramps and muscle spasms, fever, gouty attacks, flushing, weight loss, rhinorrhea
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