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Name: Isosorbide dinitrate

Pregnancy Category C

Drug classes

  • Antianginal drug
  • Nitrate

Therapeutic actions

Relaxes vascular smooth muscle with a resultant decrease in venous return and decrease in arterial blood pressure, which reduces left ventricular workload and decreases myocardial  oxygen consumption.

Indications

Treatment and prevention of angina pectoris

Contraindications/cautions

Allergy to nitrates, severe anemia, GI hypermobility (sustained-release tablets), head trauma, cerebral hemorrhage, hypertrophic cardiomyopathy, pregnancy, lactation.

Adverse effects

  • CNS: Headache, apprehension, restlessness, weakness, vertigo, dizziness, faintness
  • GI: Nausea, vomiting, incontinence or urine and feces, abdominal pain
  • CV: Tachycardia, retrosternal discomfort, palpitations, hypotension, syncope, collapse, postural hypotension, angina
  • Dermatologic: Rash, exfoliative dermatitis, cutaneous vasodilation with flushing
  • Other: Muscle twitching, pallor, perspiration, cold sweat

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