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Date of last update: 10/20/2017.

Forum Name: Hypertension

Question: Can Tylonel PM be taken when person is taking Lisinopril?

 lnore - Sat Dec 20, 2008 12:05 pm

I am taking Lisinopril/hctz, 20/12.5 mg, twice daily
I have been having trouble sleeping. Can I take Tylonel PM without any problems?
Thank you
 John Kenyon, CNA - Sat Dec 20, 2008 9:11 pm

User avatar Hi there -

Tylenol (acetaminophen) is fine with Lisonpril/HCTZ, no interactions. What makes Tylenol PM a sleep aid is a small amount of diphenhydramine (the active ingredient in Benadryl). Again, no problem there. You may feel more sleepy at night after taking Tylenol PM while taking Lisinopril/HCTZ, simply because one of the more commonly reported side effects of Lisinopril is drowsiness (also lightheadedness). If you're going to sleep anyway, this shouldn't be a problem.

Hope this helps.

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