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Brand Name: Antrizine
Name: Meclizine

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Pregnancy Category B

Drug classes of Antrizine

Antihistamines (sedating type)

Mechanism of action of Antrizine

Has central anticholinergic action by blocking the chemoreceptor trigger zone. It also decreases excitability of the middle ear labyrinth and blocks conduction in the middle ear vestibular-cerebellar pathways.

Indications of Antrizine

  1. Prevention and treatment of symptoms of motion sickness; management of vertigo and diseases affecting the vestibular system

Contraindications of Antrizine

  1. Allergy to any antihistamines

Adverse effects of Antrizine

  • CNS: Sedation, sleepiness
  • GI: Appetite increase, nausea, diarrhea, abdominal pain, dry mouth
  • CV: Palpitation, tachycardia, hypotension
  • Respiratory: Thickening of bronchial secretions
  • General: Weight gain
  • Other: Hepatitis, photosensitivity, rash, urticaria, angioedema

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