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Brand Name: Bonine
Name: Meclizine

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Pregnancy Category B

Drug classes of Bonine

Antihistamines (sedating type)

Mechanism of action of Bonine

Has central anticholinergic action by blocking the chemoreceptor trigger zone. It also decreases excitability of the middle ear labyrinth and blocks conduction in the middle ear vestibular-cerebellar pathways.

Indications of Bonine

  1. Prevention and treatment of symptoms of motion sickness; management of vertigo and diseases affecting the vestibular system

Contraindications of Bonine

  1. Allergy to any antihistamines

Adverse effects of Bonine

  • CNS: Sedation, sleepiness
  • GI: Appetite increase, nausea, diarrhea, abdominal pain, dry mouth
  • CV: Palpitation, tachycardia, hypotension
  • Respiratory: Thickening of bronchial secretions
  • General: Weight gain
  • Other: Hepatitis, photosensitivity, rash, urticaria, angioedema

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