Back to Antihistamines
Name: Chlorpheniramine
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Pregnancy Category B
Drug classes of Chlorpheniramine
Antihistamines (sedating type)
Mechanism of action of Chlorpheniramine
Competitively blocks the effects of histamine at peripheral H1 receptor sites; has sedative effects.
Indications of Chlorpheniramine
- Relief of symptoms associated with perennial and seasonal allergic rhinitis; vasomotor rhinitis; allergic conjunctivitis; mild, uncomplicated urticaria and angioedema
Contraindications of Chlorpheniramine
- Allergy to any antihistamines
- Narrow angle glaucoma
- Bladder neck obstruction
- Symptomatic prostatic hypertrophy
- Asthmatic attack
- Stenosing peptic ulcer
- Pyloroduodenal obstruction
- Not to be used in neonates (possible association with SIDS)
Adverse effects of Chlorpheniramine
- CNS: Sedation, sleepiness, headache, nervousness, dizziness, euphoria
- GI: Appetite increase, nausea, diarrhea, abdominal pain
- Respiratory: Thickening of bronchial secretions
- General: Weight gain
- Other: Photosensitivity, rash, urticaria, angioedema, urine retention
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