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Name: Clemastine

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Pregnancy Category B

Drug classes of Clemastine

Antihistamines (sedating type)

Mechanism of action of Clemastine

Competitively blocks the effects of histamine at peripheral H1 receptor sites.

Indications of Clemastine

  1. Relief of symptoms associated with perennial and seasonal allergic rhinitis; vasomotor rhinitis; allergic conjunctivitis; mild, uncomplicated urticaria and angioedema
  2. Amelioration of allergic reactions to blood or plasma
  3. Dermatographism
  4. Adjunctive therapy in anaphylactic reactions

Contraindications of Clemastine

  1. Allergy to any antihistamines
  2. Narrow angle glaucoma

Adverse effects of Clemastine

  • CNS: Sedation, sleepiness, dyscoordination, somnolence, headache, dizziness, nervousness
  • GI: Epigastric distress
  • CV: Palpitation, tachycardia, hypotension
  • Respiratory: Thickening of bronchial secretions
  • General: Weight gain
  • Other: Photosensitivity, rash, urticaria, angioedema

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