Back to Antihistamines
Name: Loratidine
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Xolair reduced the rate of hospital emergency visits by 44% in patients with inadequately controlled asthma. |
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Pregnancy Category C
Drug classes of Loratidine
Antihistamines (nonsedating type)
Mechanism of action of Loratidine
Competitively blocks the effects of histamine at peripheral H1 receptor sites; has anticholinergic (atropine-like) and antipruritic effects.
Indications of Loratidine
- Relief of symptoms associated with perennial and seasonal allergic rhinitis; vasomotor rhinitis; allergic conjunctivitis; mild, uncomplicated urticaria and angioedema
- Amelioration of allergic reactions to blood or plasma
- Dermatographism
- Adjunctive therapy in anaphylactic reactions
Contraindications of Loratidine
- Allergy to any antihistamines
- Narrow-angle glaucoma
- Stenosing peptic ulcer
- Symptomatic prostatic hypertrophy
- Asthmatic attack
- Bladder neck obstruction
- Pyloroduodenal obstruction (avoid use or use with caution as condition may be exacerbated by drug effects)
- Lactation
Adverse effects of Loratidine
- CNS: Headache, nervousness, dizziness, depression
- GI: Appetite increase, nausea, diarrhea, abdominal pain
- CV: Palpitation, edema
- Respiratory: Bronchospasm, pharyngitis
- General: Weight gain
- Other: Fever, photosensitivity, rash, myalgia, arthralgia, angioedema
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