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Name: Meclizine

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Drug classes of Meclizine

Antihistamines (sedating type)

Mechanism of action of Meclizine

Has central anticholinergic action by blocking the chemoreceptor trigger zone. It also decreases excitability of the middle ear labyrinth and blocks conduction in the middle ear vestibular-cerebellar pathways.

Indications of Meclizine

Prevention and treatment of symptoms of motion sickness; management of vertigo and diseases affecting the vestibular system

Contraindications of Meclizine

Allergy to any antihistamines

Adverse effects of Meclizine

CNS: Sedation, sleepiness
GI: Appetite increase, nausea, diarrhea, abdominal pain, dry mouth
CV: Palpitation, tachycardia, hypotension
Respiratory: Thickening of bronchial secretions
General: Weight gain
Other: Hepatitis, photosensitivity, rash, urticaria, angioedema

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